USC vs Penn State Prediction, Picks & Odds (Week 6)

Sat, Oct 10, 7:30 PM ET

Market favorite

Penn State moneyline -120, published Oct 3, 2026, 12:28 PM ET.

About this pick

Penn State is the market favorite on the moneyline at -120 when the pick was published on Oct 3. Until our ratings model is live, each pick is the market favorite, and that price implies a 55% chance of Penn State winning.

Line movement: the Penn State spread has moved from +1.5 to -1.5 since Oct 4 (partner sportsbooks); the total has moved from 55.5 to 55 since Oct 4 (partner sportsbooks).

This season, USC is 4-1 with 199 points for and 132 against; Penn State is 3-2 with 160 points for and 80 against.

USC is 4-1 in its last 5, averaging 39.8 scored and 26.4 allowed; most recently losing to Oregon 27-41 on September 26, 2026. Penn State is 3-2 in its last 5, averaging 32.0 scored and 16.0 allowed; most recently losing to Northwestern 13-34 on October 2, 2026.

Injury report: USC list none; Penn State lists 2 (Koby Howard, Injured; Cooper Alexander, Injured).

USC vs Penn State odds

American odds, main line. The best price in each column is in bold.

Sportsbook	USC ML	Penn State ML	USC spread	Penn State spread	Over	Under
BetOnline	—	—	+1.5 -110	-1.5 -110	O 55 -110	U 55 -110

Line movement

Penn State spread: +1.5 → -1.5 since Oct 4 (partner sportsbooks)
total: 55.5 → 55 since Oct 4 (partner sportsbooks)

Injuries

USC

None listed.

Penn State

Koby Howard: Injured, Undisclosed
Cooper Alexander: Injured, Undisclosed

Recent form

USC

September 26, 2026: L 27-41 vs Oregon
September 19, 2026: W 42-35 at Rutgers
September 12, 2026: W 49-30 vs Louisiana
September 4, 2026: W 39-0 vs Fresno State

Penn State

October 2, 2026: L 13-34 at Northwestern
September 26, 2026: L 20-24 vs Wisconsin
September 19, 2026: W 55-13 vs Buffalo
September 12, 2026: W 27-9 at Temple
September 5, 2026: W 45-0 vs Marshall

More on this game

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