Louisville vs Syracuse Prediction, Picks & Odds (Week 7)
Sun, Oct 18, 12:00 AM ET
About this game
This season, Louisville is 2-2 with 165 points for and 115 against; Syracuse is 1-2 with 97 points for and 51 against.
Louisville is 3-2 in its last 5, averaging 38.4 scored and 27.4 allowed; most recently losing to Wake Forest 27-30 on September 26, 2026. Syracuse is 1-4 in its last 5, averaging 23.2 scored and 31.0 allowed; most recently losing to Pittsburgh 13-27 on September 17, 2026.
Injury report: Louisville lists 4 (Montavin Quisenberry, Injured; Hamilton Atkins, Injured; Travis Egan, Injured; more below); Syracuse lists 8 (Steve Angeli, Injured; Ju'Juan Johnson, Injured; Nate Edwards, Injured; more below).
Injuries
Louisville
- Montavin Quisenberry: Injured, Undisclosed
- Hamilton Atkins: Injured, Undisclosed
- Travis Egan: Injured, Undisclosed
- Daylen Russell: Injured, Undisclosed
Syracuse
- Steve Angeli: Injured, Undisclosed
- Ju'Juan Johnson: Injured, Hand
- Nate Edwards: Injured, Undisclosed
- Terrell Wilfong: Injured, Collarbone
- Wyatt Bowman: Injured, Undisclosed
- Elijah Crawford: Injured, Collarbone
- Jai Eugene Jr.: Injured, Undisclosed
- Chase Geter: Injured, Hand
Recent form
Louisville
- September 26, 2026: L 27-30 vs Wake Forest
- September 19, 2026: W 41-31 vs SMU
- September 11, 2026: W 59-13 vs Villanova
- September 6, 2026: L 38-41 at Ole Miss
- December 23, 2025: W 27-22 vs Toledo
Syracuse
- September 17, 2026: L 13-27 at Pittsburgh
- September 12, 2026: L 18-21 vs California
- September 5, 2026: W 66-3 vs New Hampshire
- November 29, 2025: L 12-34 vs Boston College
- November 22, 2025: L 7-70 at Notre Dame