Louisiana vs Southern Miss Prediction, Picks & Odds (Week 8)
Sun, Oct 25, 12:00 AM ET
Why we pick this side
This season, Louisiana is 3-1 with 123 points for and 77 against; Southern Miss is 1-3 with 98 points for and 118 against.
Louisiana is 3-2 in its last 5, averaging 27.2 scored and 19.4 allowed; most recently beating Charlotte 34-7 on September 26, 2026. Southern Miss is 1-4 in its last 5, averaging 22.8 scored and 29.0 allowed; most recently losing to Tulane 21-24 on September 26, 2026.
These teams have met once in our results history, on October 18, 2025: Southern Miss 22, Louisiana 10.
Injury report: Louisiana list none; Southern Miss lists 8 (Ethan Hampton, Injured; Robert Briggs, Injured; Jaylen Himes, Injured; more below).
Injuries
Louisiana
None listed.
Southern Miss
- Ethan Hampton: Injured, Hand
- Robert Briggs: Injured, Undisclosed
- Jaylen Himes: Injured, Foot
- Grant Page: Injured, Elbow
- Nasim Cairo: Injured, Hand
- Jameer Lewis: Injured, Foot
- Mathis Haygood: Injured, Elbow
- Tyler Lassiter: Injured, Undisclosed
Recent form
Louisiana
- September 26, 2026: W 34-7 at Charlotte
- September 19, 2026: W 21-14 vs UAB
- September 12, 2026: L 30-49 at USC
- September 5, 2026: W 38-7 vs Lamar
- December 17, 2025: L 13-20 at Delaware
Southern Miss
- September 26, 2026: L 21-24 at Tulane
- September 19, 2026: L 20-48 vs UConn
- September 12, 2026: L 8-43 at Auburn
- September 5, 2026: W 49-3 vs Alcorn State
- December 23, 2025: L 16-27 vs Western Kentucky
Head to head
- October 18, 2025: Southern Miss 22, Louisiana 10