James Madison vs Southern Miss Prediction, Picks & Odds (Week 10)
Thu, Nov 5, 8:00 PM ET
Why we pick this side
This season, James Madison is 4-0 with 179 points for and 49 against; Southern Miss is 1-3 with 98 points for and 118 against.
James Madison is 4-1 in its last 5, averaging 42.6 scored and 20.0 allowed; most recently beating Old Dominion 46-20 on September 26, 2026. Southern Miss is 1-4 in its last 5, averaging 22.8 scored and 29.0 allowed; most recently losing to Tulane 21-24 on September 26, 2026.
Injury report: James Madison lists 4 (JC Evans, Injured; Za'Ron Collins, Injured; Lathan Croley, Injured; more below); Southern Miss lists 8 (Ethan Hampton, Injured; Robert Briggs, Injured; Jaylen Himes, Injured; more below).
Injuries
James Madison
- JC Evans: Injured, Wrist
- Za'Ron Collins: Injured, Undisclosed
- Lathan Croley: Injured, Undisclosed
- Damier Minkah: Injured, Wrist
Southern Miss
- Ethan Hampton: Injured, Hand
- Robert Briggs: Injured, Undisclosed
- Jaylen Himes: Injured, Foot
- Grant Page: Injured, Elbow
- Nasim Cairo: Injured, Hand
- Jameer Lewis: Injured, Foot
- Mathis Haygood: Injured, Elbow
- Tyler Lassiter: Injured, Undisclosed
Recent form
James Madison
- September 26, 2026: W 46-20 at Old Dominion
- September 19, 2026: W 26-13 at San Diego State
- September 12, 2026: W 87-3 vs Wagner
- September 5, 2026: W 20-13 vs Liberty
- December 20, 2025: L 34-51 at Oregon
Southern Miss
- September 26, 2026: L 21-24 at Tulane
- September 19, 2026: L 20-48 vs UConn
- September 12, 2026: L 8-43 at Auburn
- September 5, 2026: W 49-3 vs Alcorn State
- December 23, 2025: L 16-27 vs Western Kentucky