Illinois vs Michigan State Prediction, Picks & Odds (Week 6)
Sat, Oct 10, 3:30 PM ET
Market favorite
Illinois moneyline -182, published Oct 4, 2026, 10:30 AM ET.
About this pick
Illinois is the market favorite on the moneyline at -182 when the pick was published on Oct 4. Until our ratings model is live, each pick is the market favorite, and that price implies a 65% chance of Illinois winning.
This season, Illinois is 2-2 with 136 points for and 106 against; Michigan State is 2-2 with 88 points for and 85 against.
Illinois is 3-2 in its last 5, averaging 33.2 scored and 26.8 allowed; most recently losing to Ohio State 19-42 on September 26, 2026. Michigan State is 3-2 in its last 5, averaging 25.2 scored and 22.6 allowed; most recently losing to Nebraska 13-31 on September 26, 2026.
Injury report: Illinois lists 8 (Ca'Lil Valentine, Injured; Jayshon Platt, Injured; Kaden Feagin, Injured; more below); Michigan State lists 7 (Cam Fancher, Injured; Cam Edwards, Injured; Jay Coyne, Injured; more below).
Injuries
Illinois
- Ca'Lil Valentine: Injured, Undisclosed
- Jayshon Platt: Injured, Undisclosed
- Kaden Feagin: Injured, Undisclosed
- Tanner Hollinger: Injured, Undisclosed
- Grant Smith: Injured, Undisclosed
- BJ Thurman: Injured, Foot
- Jakwon Morris: Injured, Undisclosed
- Xavier Scott: Injured, Undisclosed
Michigan State
- Cam Fancher: Injured, Knee
- Cam Edwards: Injured, Knee
- Jay Coyne: Injured, Undisclosed
- Joe Caudill: Injured, Undisclosed
- Caleb Wheatland: Injured, Undisclosed
- NiJhay Burt: Injured, Knee
- Devin Vaught: Injured, Knee
Recent form
Illinois
- September 26, 2026: L 19-42 at Ohio State
- September 19, 2026: W 48-10 vs Southern Illinois
- September 12, 2026: L 27-31 vs Duke
- September 3, 2026: W 42-23 vs UAB
- December 30, 2025: W 30-28 vs Tennessee
Michigan State
- September 26, 2026: L 13-31 vs Nebraska
- September 19, 2026: L 10-27 at Notre Dame
- September 12, 2026: W 35-7 vs Eastern Michigan
- September 4, 2026: W 30-20 vs Toledo
- November 29, 2025: W 38-28 vs Maryland