Florida State vs Louisville Prediction, Picks & Odds (Week 6)
Fri, Oct 9, 7:00 PM ET
Market favorite
Louisville moneyline -250, published Oct 4, 2026, 10:26 AM ET.
About this pick
Louisville is the market favorite on the moneyline at -250 when the pick was published on Oct 4. Until our ratings model is live, each pick is the market favorite, and that price implies a 71% chance of Louisville winning.
Line movement: the Louisville spread has moved from -6.5 to -5 since Oct 4 (partner sportsbooks).
This season, Florida State is 2-2 with 128 points for and 101 against; Louisville is 2-2 with 165 points for and 115 against.
Florida State is 2-3 in its last 5, averaging 29.8 scored and 28.2 allowed; most recently beating Central Arkansas 34-7 on September 26, 2026. Louisville is 3-2 in its last 5, averaging 38.4 scored and 27.4 allowed; most recently losing to Wake Forest 27-30 on September 26, 2026.
Injury report: Florida State lists 6 (Jaden O'Neal, Injured; Samuel Singleton Jr., Injured; Devin Carter, Injured; more below); Louisville lists 4 (Montavin Quisenberry, Injured; Hamilton Atkins, Injured; Travis Egan, Injured; more below).
Florida State vs Louisville odds
American odds, main line. The best price in each column is in bold.
| Sportsbook | Florida State ML | Louisville ML | Florida State spread | Louisville spread | Over | Under |
|---|---|---|---|---|---|---|
| BetOnline | — | — | +5 -110 | -5 -110 | O 57.5 -110 | U 57.5 -110 |
Line movement
- Louisville spread: -6.5 → -5 since Oct 4 (partner sportsbooks)
Injuries
Florida State
- Jaden O'Neal: Injured, Undisclosed
- Samuel Singleton Jr.: Injured, Lower Body
- Devin Carter: Injured, Back
- Mandrell Desir: Injured, Lower Body
- Karson Hobbs: Injured, Undisclosed
- CJ Richard Jr.: Injured, Back
Louisville
- Montavin Quisenberry: Injured, Undisclosed
- Hamilton Atkins: Injured, Undisclosed
- Travis Egan: Injured, Undisclosed
- Daylen Russell: Injured, Undisclosed
Recent form
Florida State
- September 26, 2026: W 34-7 vs Central Arkansas
- September 19, 2026: L 36-50 at Alabama
- September 7, 2026: L 24-27 vs SMU
- August 29, 2026: W 34-17 vs New Mexico State
- November 29, 2025: L 21-40 at Florida
Louisville
- September 26, 2026: L 27-30 vs Wake Forest
- September 19, 2026: W 41-31 vs SMU
- September 11, 2026: W 59-13 vs Villanova
- September 6, 2026: L 38-41 at Ole Miss
- December 23, 2025: W 27-22 vs Toledo
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