Clemson vs Syracuse Prediction, Picks & Odds (Week 10)
Sun, Nov 8, 12:00 AM ET
Why we pick this side
This season, Clemson is 3-1 with 84 points for and 88 against; Syracuse is 1-2 with 97 points for and 51 against.
Clemson is 3-2 in its last 5, averaging 18.8 scored and 22.0 allowed; most recently beating California 24-10 on September 25, 2026. Syracuse is 1-4 in its last 5, averaging 23.2 scored and 31.0 allowed; most recently losing to Pittsburgh 13-27 on September 17, 2026.
These teams have met once in our results history, on September 20, 2025: Syracuse 34, Clemson 21.
Injury report: Clemson lists 8 (David Eziomume, Injured; Jay Haynes, Injured; Peyton Streko, Injured; more below); Syracuse lists 8 (Steve Angeli, Injured; Ju'Juan Johnson, Injured; Nate Edwards, Injured; more below).
Injuries
Clemson
- David Eziomume: Injured, Leg
- Jay Haynes: Injured, Personal
- Peyton Streko: Injured, Undisclosed
- Cole Turner: Injured, Personal
- C.J. Wesley: Injured, Undisclosed
- Logan Anderson: Injured, Leg
- C.J. KubahTaylor: Injured, Personal
- Corey Myrick: Injured, Personal
Syracuse
- Steve Angeli: Injured, Undisclosed
- Ju'Juan Johnson: Injured, Hand
- Nate Edwards: Injured, Undisclosed
- Terrell Wilfong: Injured, Collarbone
- Wyatt Bowman: Injured, Undisclosed
- Elijah Crawford: Injured, Collarbone
- Jai Eugene Jr.: Injured, Undisclosed
- Chase Geter: Injured, Hand
Recent form
Clemson
- September 25, 2026: W 24-10 at California
- September 19, 2026: W 28-20 vs North Carolina
- September 12, 2026: W 22-7 vs Georgia Southern
- September 5, 2026: L 10-51 at LSU
- December 27, 2025: L 10-22 vs Penn State
Syracuse
- September 17, 2026: L 13-27 at Pittsburgh
- September 12, 2026: L 18-21 vs California
- September 5, 2026: W 66-3 vs New Hampshire
- November 29, 2025: L 12-34 vs Boston College
- November 22, 2025: L 7-70 at Notre Dame
Head to head
- September 20, 2025: Syracuse 34, Clemson 21