Cleveland Cavaliers vs Philadelphia 76ers Prediction, Picks & Odds (Oct 22, 2026)
Thu, Oct 22, 7:10 PM ET
Our pick
Philadelphia 76ers moneyline -172, published Aug 19, 2026, 9:16 PM ET.
Why we pick Philadelphia 76ers
We pick Philadelphia 76ers on the moneyline at -172 when we published it on Aug 19. We back the side the odds favor, and that price implies a 63% chance of the 76ers winning.
The Cavaliers are 1-4 in their last 5, averaging 104.6 scored and 113.8 allowed; most recently losing to New York Knicks 93-130 on May 25, 2026. The 76ers are 1-4 in their last 5, averaging 103.4 scored and 119.4 allowed; most recently losing to New York Knicks 114-144 on May 10, 2026.
In the last 4 meetings in our results history, the 76ers have won 0 and the Cavaliers 4. The most recent was on March 9, 2026: Philadelphia 76ers 101, Cleveland Cavaliers 115.
Injury report: the Cavaliers list none; the 76ers list 1 (Adem Bona, Questionable).
Cleveland Cavaliers vs Philadelphia 76ers odds
American odds, main line. The best price in each column is in bold.
| Sportsbook | Cleveland Cavaliers ML | Philadelphia 76ers ML | Cleveland Cavaliers spread | Philadelphia 76ers spread | Over | Under |
|---|---|---|---|---|---|---|
| BetOnline | — | — | +4.5 -110 | -4.5 -110 | O 233 -105 | U 233 -115 |
Injuries
Cleveland Cavaliers
None listed.
Philadelphia 76ers
- Adem Bona: Questionable, Foot - Questionable for start of season
Recent form
Cleveland Cavaliers
- May 25, 2026: L 93-130 vs New York Knicks
- May 23, 2026: L 108-121 vs New York Knicks
- May 21, 2026: L 93-109 at New York Knicks
- May 19, 2026: L 104-115 at New York Knicks
- May 17, 2026: W 125-94 at Detroit Pistons
Philadelphia 76ers
- May 10, 2026: L 114-144 vs New York Knicks
- May 8, 2026: L 94-108 vs New York Knicks
- May 6, 2026: L 102-108 at New York Knicks
- May 4, 2026: L 98-137 at New York Knicks
- May 2, 2026: W 109-100 at Boston Celtics
Head to head
- March 9, 2026: Philadelphia 76ers 101, Cleveland Cavaliers 115
- January 16, 2026: Cleveland Cavaliers 117, Philadelphia 76ers 115
- January 14, 2026: Cleveland Cavaliers 133, Philadelphia 76ers 107
- November 5, 2025: Philadelphia 76ers 121, Cleveland Cavaliers 132
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