Patriots at Bills Pick, Odds & Prediction – NFL Week 4

Patriots at Bills

Sun, Oct 4, 1:00 PM ET · Status: Final · Highmark Stadium, Orchard Park

Final: Patriots 29, Bills 26

Our pick and the result

No pick

Line moves

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Matchup

Recent results

Patriots

• L 6-35 at Jacksonville Jaguars, September 27
• W 20-3 vs Pittsburgh Steelers, September 20
• L 10-13 at Seattle Seahawks, September 9
• L 13-29 vs Seattle Seahawks, February 8 (2025 playoffs)
• W 10-7 at Denver Broncos, January 25 (2025 playoffs)

Bills

• W 24-16 vs Los Angeles Chargers, September 27
• W 41-31 vs Detroit Lions, September 17
• W 36-31 at Houston Texans, September 13
• L 30-33 at Denver Broncos, January 17 (2025 playoffs)
• W 27-24 at Jacksonville Jaguars, January 11 (2025 playoffs)

Head to head

• December 14, 2025: Buffalo Bills 35, New England Patriots 31
• October 5, 2025: New England Patriots 23, Buffalo Bills 20
• January 5, 2025: Buffalo Bills 16, New England Patriots 23
• December 22, 2024: New England Patriots 21, Buffalo Bills 24

Match preview

The Patriots won 29-26.

In 3 games this season, the Patriots have scored 12.0 points a game and allowed 17.0. The Patriots lost to the Jacksonville Jaguars 35-6 on September 27. In 3 games this season, the Bills have scored 33.7 points a game and allowed 26.0. On September 27, the Bills beat the Los Angeles Chargers 24-16.

Next NFL games

• Pittsburgh Steelers at New Orleans Saints, Oct 25, 9:30 AM ET. Pick: Pittsburgh Steelers, posted at -141 · Bet Pittsburgh Steelers -167 at BetOnline →
• San Francisco 49ers at Atlanta Falcons, Oct 25, 1:00 PM ET. Pick: San Francisco 49ers, posted at -233 · Bet San Francisco 49ers -145 at BetUS →
• Cleveland Browns at Tennessee Titans, Oct 25, 1:00 PM ET. Pick: Cleveland Browns, posted at -127 · Bet Cleveland Browns -128 at BetOnline →
• Indianapolis Colts at Minnesota Vikings, Oct 25, 1:00 PM ET. Pick: Minnesota Vikings, posted at -238 · Bet Minnesota Vikings -278 at BetOnline →

Other NFL Week 4 games

• Steelers at Browns, Oct 1, 8:15 PM ET
• Colts at Commanders, Oct 4, 9:30 AM ET
• Cardinals at Giants, Oct 4, 1:00 PM ET
• Titans at Ravens, Oct 4, 1:00 PM ET
• Cowboys at Texans, Oct 4, 1:00 PM ET
• Packers at Buccaneers, Oct 4, 1:00 PM ET
• Jets at Bears, Oct 4, 1:00 PM ET
• Rams at Eagles, Oct 4, 1:00 PM ET
• Jaguars at Bengals, Oct 4, 1:00 PM ET
• Dolphins at Vikings, Oct 4, 4:05 PM ET
• Broncos at 49ers, Oct 4, 4:25 PM ET
• Chiefs at Raiders, Oct 4, 4:25 PM ET
• Chargers at Seahawks, Oct 4, 4:25 PM ET
• Lions at Panthers, Oct 4, 8:20 PM ET
• Falcons at Saints, Oct 5, 8:15 PM ET

All NFL picks · NFL odds

Patriots vs Bills FAQ

Who is favored in Patriots vs Bills?

The game is over: Patriots 29, Bills 26.

What is the spread for Patriots vs Bills?

The spread closed when the game started.

What is the over/under for Patriots vs Bills?

The over/under closed when the game started.

When and where is Patriots vs Bills?

The Patriots play the Bills on Sunday, October 4 at 1:00 PM ET at Highmark Stadium, Orchard Park.