Chicago White Sox vs Cleveland Guardians Prediction, Picks & Odds (Oct 5, 2026)
Mon, Oct 5, 5:10 PM ET
Our pick
Cleveland Guardians moneyline -156, published Oct 4, 2026, 8:56 AM ET.
Why we pick Cleveland Guardians
We pick Cleveland Guardians on the moneyline at -156 when we published it on Oct 4. We back the side the odds favor, and that price implies a 61% chance of the Guardians winning. On the moneyline, the margin-free consensus across 4 of our partner sportsbooks gives the Guardians 58.3%, and the best price available is -149 at BetOnline.
Line movement: the Cleveland Guardians moneyline has moved from -164 to -149 since Oct 3 (partner sportsbooks).
This season, the White Sox are 84-78 with 776 runs scored and 720 allowed, 36-45 on the road; the Guardians are 85-77 with 678 runs scored and 667 allowed, 41-40 at home.
The White Sox are 4-1 in their last 5, averaging 5.2 scored and 3.4 allowed; most recently beating Cleveland Guardians 3-0 on October 3, 2026. The Guardians are 3-2 in their last 5, averaging 5.2 scored and 4.0 allowed; most recently losing to Chicago White Sox 0-3 on October 3, 2026.
In the last 5 meetings in our results history, the Guardians have won 2 and the White Sox 3. The most recent was on October 3, 2026: Chicago White Sox 3, Cleveland Guardians 0.
Market vs best price
We don't run a projection model. This compares the sportsbooks' own view with the best price you can get.
- Consensus win probability for Cleveland Guardians (margin removed, 4 books)
- 58.3%
- Best price
- -149 at BetOnline (59.9% implied)
- Difference
- -1.6 points
Chicago White Sox vs Cleveland Guardians odds
American odds, main line. The best price in each column is in bold.
| Sportsbook | Chicago White Sox ML | Cleveland Guardians ML | Chicago White Sox spread | Cleveland Guardians spread | Over | Under |
|---|---|---|---|---|---|---|
| MyBookie | +128 | -152 | +1.5 -169 | -1.5 +150 | O 6.5 -123 | U 6.5 +101 |
| Bovada | +131 | -156 | +1.5 -175 | -1.5 +150 | O 6.5 -125 | U 6.5 +105 |
| BetOnline | +136 | -149 | +1.5 -175 | -1.5 +153 | O 6.5 -120 | U 6.5 +100 |
| BetUS | +134 | -149 | +1.5 -175 | -1.5 +152 | O 6.5 -120 | U 6.5 +100 |
Line movement
- Cleveland Guardians moneyline: -164 → -149 since Oct 3 (partner sportsbooks)
Injuries
Chicago White Sox
- Drew Thorpe: Sidelined, Elbow - Expected to be out until at least Sep 16
- Tommy Pham: Sidelined, Calf - Expected to be out until at least Sep 16
- Huascar Brazoban: Sidelined, Lat - Expected to be out until at least Sep 16
- Tanner Murray: Sidelined, Shoulder - Expected to be out until at least Sep 16
- Prelander Berroa: Sidelined, Elbow - Expected to be out until at least Sep 22
- Ky Bush: Sidelined, Elbow - Expected to be out until at least Feb 1
- Jordan Leasure: Sidelined, Forearm - Expected to be out until at least Feb 1, 2028
- Joey Bart: Sidelined, Hand - Expected to be out until at least Sep 17
- Brooks Baldwin: Sidelined, Elbow - Expected to be out until at least Feb 1
- Mike Vasil: Sidelined, Elbow - Expected to be out until at least Jul 1
Cleveland Guardians
- Chase DeLauter: Questionable, Wrist - Questionable for Sep 16
- Angel Martinez: Questionable, Side - Questionable for Sep 16
- Rhys Hoskins: Sidelined, Back - Expected to be out until at least Sep 22
- Colin Holderman: Sidelined, Wrist - Expected to be out until at least Sep 19
- Shawn Armstrong: Sidelined, Calf - Expected to be out until at least Sep 23
Recent form
Chicago White Sox
- October 3, 2026: W 3-0 at Cleveland Guardians
- September 30, 2026: W 7-3 at Houston Astros
- September 29, 2026: W 6-3 at Houston Astros
- September 27, 2026: W 4-2 vs Colorado Rockies
- September 26, 2026: L 6-9 vs Colorado Rockies
Cleveland Guardians
- October 3, 2026: L 0-3 vs Chicago White Sox
- September 27, 2026: L 2-3 at Kansas City Royals
- September 26, 2026: W 11-5 at Kansas City Royals
- September 25, 2026: W 12-9 at Kansas City Royals
- September 24, 2026: W 1-0 at Boston Red Sox
Head to head
- October 3, 2026: Chicago White Sox 3, Cleveland Guardians 0
- September 16, 2026: Chicago White Sox 3, Cleveland Guardians 6
- September 15, 2026: Chicago White Sox 6, Cleveland Guardians 7
- September 14, 2026: Chicago White Sox 7, Cleveland Guardians 3
- August 9, 2026: Cleveland Guardians 3, Chicago White Sox 5
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