Pistons at 76ers Pick, Odds & Prediction – NBA, October 25

Pistons (2-0) at 76ers (2-0)

Sun, Oct 25, 7:30 PM ET · Status: Scheduled · Xfinity Mobile Arena, Philadelphia, PA

Our pick

Pick posts when lines open

Pistons at 76ers odds

Last updated Oct 24, 8:51 PM ET

Pistons at 76ers: Moneyline
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Pistons at 76ers: Spread
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Pistons at 76ers: Total
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American odds. The best price on each side is in bold. OFF: the book isn't showing this line right now.

Line moves

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Matchup

Recent results

Pistons

  • W 128-111 at Miami Heat, October 23
  • W 121-113 vs Boston Celtics, October 20
  • W 129-125 vs Toronto Raptors, October 16 (2026-27 preseason)
  • W 128-106 at Minnesota Timberwolves, October 14 (2026-27 preseason)
  • L 108-114 at Washington Wizards, October 10 (2026-27 preseason)

76ers

  • W 114-106 vs Cleveland Cavaliers, October 22
  • W 106-100 at New York Knicks, October 20
  • L 120-125 vs Boston Celtics, October 16 (2026-27 preseason)
  • L 106-144 at Boston Celtics, October 10 (2026-27 preseason)
  • L 108-114 at Brooklyn Nets, October 8 (2026-27 preseason)

Head to head

  • April 4, 2026: Detroit Pistons 116, Philadelphia 76ers 93
  • March 12, 2026: Philadelphia 76ers 109, Detroit Pistons 131
  • November 14, 2025: Philadelphia 76ers 105, Detroit Pistons 114
  • November 9, 2025: Detroit Pistons 111, Philadelphia 76ers 108

Injury report

Pistons

  • Jalen Duren – Thigh (game time decision)
  • Ausar Thompson – Undisclosed (game time decision)

76ers

  • LeBron James – Back (game time decision)
  • Dean Wade – Ankle (game time decision)
  • Tacko Fall – Sidelined (quadriceps)
  • Dom Barlow – Sidelined (back)

Match preview

No book we compare has posted a moneyline yet. Our pick posts when the books open lines.

The 76ers (2-0) host the Pistons (2-0). The Pistons have averaged 124.5 points scored and 112.0 allowed in 2 games this season. Latest game for the Pistons: a 128-111 win over the Miami Heat. The 76ers have averaged 110.0 points scored and 103.0 allowed in 2 games this season. Latest game for the 76ers: a 114-106 win over the Cleveland Cavaliers.

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Pistons vs 76ers FAQ

Who is favored in Pistons vs 76ers?

None of the four sportsbooks we compare has posted a moneyline yet. This answer updates when they do.

What is the spread for Pistons vs 76ers?

No sportsbook we compare has posted a spread yet. This answer updates when they do.

What is the over/under for Pistons vs 76ers?

No sportsbook we compare has posted a total yet. This answer updates when they do.

When and where is Pistons vs 76ers?

The Pistons play the 76ers on Sunday, October 25 at 7:30 PM ET at Xfinity Mobile Arena, Philadelphia, PA.

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